| Leicester | 0 - 1 | Man United |
| bình dương | 2 - 1 | Viettel |
| thành phố hà nội | 0 - 3 | Bình Định |
| Atalanta | 3 - 1 | Torino |
| Bologna | 1 - 1 | Salernitana |
| Anderlecht | 0 - 1 | Gent |
| AZ Alkmaar | 1 - 1 | NEC Nijmegen |
| Suwon FC | 2 - 2 | Jeju United |
| Consadole Sapporo | 2 - 1 | Cerezo Osaka |
| Incheon United | 0 - 1 | Gangwon FC |
| Telstar | 0 - 1 | De Graafschap |
| milimet Platinum | 2 - 0 | JDR Stars |
| Platinum thành phố Rovers | 0 - 1 | Cape Town All Stars |
| Eintracht Braunschwei | 4 - 2 | 1. FC Nuremberg |
| FC Heidenheim | 2 - 1 | Fortuna Dusseldorf |
| Bình Phước | 0 - 1 | Khánh Hòa |
| Vũng Tàu | 1 - 1 | Phố Hiến |
| nong Bua Pitchaya FC | 0 - 2 | Ratchaburi FC |
| Kedah | 1 - 0 | Pulau Pinang |
| SV Horn | 3 - 1 | FC Liefering |
| SV Lafnitz | 3 - 0 | First Vienna FC |
| Balestier Khalsa FC | 3 - 5 | Albirex Niigata FC |
| Al-Futowa | 20:00 Hoãn | Tishreen |
| Al-Karamah | 20:00 Hoãn | Al-Ittihad |
| Al-Taleiah | 20:00 Hoãn | Al-Wathbah |
| FK Slutsk | 1 - 0 | Arsenal Dzerzhinsk |
| Dinamo Brest | 3 - 1 | FC Minsk |
| Atletico Nacional | 1 - 1 | Envigado |
| Pirin Blagoevgrad | 2 - 1 | Botev Vratsa |
| Shenyang Urban FC | 0 - 2 | Zibo Sunday |
| Xinjiang Tianshan | 0 - 2 | Shaanxi Changan |
| Atletico de San Luis | 0 - 0 | Tijuana |
| Queretaro FC | 1 - 1 | Puebla |
| FC Alashkert | 3 - 0 | Shirak |
| NK Hrvatski Dragovoljac | 1 - 1 | NK Croatia Zmijavci |
| Aris Limassol | 5 - 0 | Olympiakos Nicosia |
| Aragua FC | 03:00 Hoãn | Academia Puerto Cabello |
| Carabobo FC | 03:00 Hoãn | Estudiantes Merida |
| Deportivo La Guaira | 03:00 Hoãn | Universidad Central |
| Deportivo Lara | 03:00 Hoãn | Mineros De Guayana |
| Deportivo Tachira | 03:00 Hoãn | Hermanos Colmenarez |
| Metropolita FC | 03:00 Hoãn | Zulia |
| Portuguesa FC | 03:00 Hoãn | Monagas SC |
| Zamora FC | 03:00 Hoãn | Caracas |
| Universidad Central | 1 - 1 | Zamora FC |
| Hermanos Colmenarez | 0 - 2 | Deportivo La Guaira |
| Rukh Lviv | 0 - 1 | Shakhtar Donetsk |
| Fremad Amager | 1 - 0 | Hilleroed |
| Klaksvik | 1 - 1 | B36 Torshavn |
| Sandvikens IF | 0 - 2 | Sirius |
| Vaestra Froelunda | 1 - 2 | Utsiktens BK |
| Orebro Syrianska | 0 - 3 | Djurgaarden |
| Dinamo Batumi | 4 - 0 | FC Telavi |
| Dinamo Tbilisi | 5 - 0 | Lokomotivi Tbilisi |
| Budapest Honved | 0 - 0 | Ujpest |
| Gorica | 0 - 0 | Mura |
| Koper | 0 - 2 | NK Celje |
| Zilina | 0 - 1 | Zeleziarne Podbrezova |
| FC STK 1914 Samorin | 3 - 1 | Humenne |
| FH Hafnarfjord | 2 - 1 | KA Akureyri |
| Hermannstad | 1 - 0 | CS Universitat Craiova |
| Sepsi OSK | 0 - 1 | CS Mioveni |
| Steaua Bucuresti | 2 - 1 | CSM Politehnica Iasi |
| Zaglebie Sosnowiec | 1 - 0 | Stal Rzeszow |
| Arka Gdynia | 0 - 0 | Gornik Leczna |
| Ruch Chorzow | 0 - 1 | Gornik Zabrze |
